Abstract Background Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in the development of osteolysis. with endoplasmic reticulum (ER) stress identified as a key underlying mechanism. Therefore. https://loungesunderwear.shop/product-category/accessories/