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Inhibitory properties of PD-1 receptor engagement on activated T cells are well established in physiologic and pathological contexts. In cancer. the use of checkpoint blockade. such as anti-PD-1 antibodies.

Device emulation is a common necessity that arises at various steps of the development cycle. hardware migration. or reverse-engineering. While implementing the algorithms behind the device may be a nontrivial task by itself.

Bullous pemphigoid (BP) is an autoimmune sub-epidermal blistering disorder of the skin. The association of BP with internal malignancy has always been a matter of debate with no consensus reached despite many published case reports and clinical trials. However. we report a hitherto unreported association of BP with squamous cell carcinoma of the tongue.

The integron is a genetic element that incorporates mobile genes termed gene cassettes into a reserved genetic site via site-specific recombination. It is best known for its role in antibiotic resistance with one type of integron. the class 1 integron. a major player in the dissemination of antibiotic resistance genes across Gram negative pathogens and commensals.

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