How duplicate genes provide genetic robustness remains an unresolved question. We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can provide genetic robustness against null mutations through a substitution mechanism. Hst1p is an NAD(+)-dependent histone deacetylase that acts with... https://www.spidertattooz.com/Patchwork-Barn-Quilt-Pattern-by-Edyta-Sitar/